The manufacturer reveals: Why is ergothioneine becoming a favorite ingredient among leading brands?
Publish Time:
2025-11-07
Ergothioneine (EGT), chemically known as 2-mercapto-histidine trimethylhydrazinium, is a naturally occurring, water-soluble sulfur-containing amino acid and a highly effective antioxidant.
In 1909, French pharmacist Charles Tanret first isolated ergothioneine from the ergot fungus, after which the compound was named. Ergothioneine is present in various tissues and organs throughout the human body, yet the human body cannot synthesize it on its own—it must be obtained externally, with dietary sources primarily coming from mushrooms.
Ergothioneine structural formula
Cosmetics containing ergothioneine available on the market are mostly high-end products from internationally renowned brands. Estée Lauder has even made it one of its signature ingredients, with derivatives like Clinique and La Mer—including their entire product lines—incorporating it.
So, why has ergothioneine become a favorite ingredient among major brands? The main reasons are as follows:
1.1 Naturally Safe: Ergothioneine naturally occurs in the human body, and toxicological studies have revealed no adverse evidence, making it suitable for all skin types. Not only is it a popular ingredient in cosmetics, but it has also been approved by countries and regions such as Europe, the U.S., Japan, and others as an ingredient for food and dietary supplements.
1.2 Exceptionally Strong Antioxidant: Studies show that ergothioneine's antioxidant capacity surpasses that of classic antioxidants such as CoQ10 and idebenone.
1.3 Directly to Cellular Mitochondria Although the human body cannot synthesize ergothioneine, it possesses a unique transporter protein called OCTN1, which efficiently delivers this compound into cells, as well as into the nucleus and mitochondria, where it specifically targets and neutralizes free radicals.
1.4 Can accumulate in skin cells—unlike other common antioxidants (such as glutathione, ascorbic acid, etc.), it is not rapidly metabolized after being absorbed by the body, allowing it to build up to higher levels in tissues and exert a more potent effect.
1.5 Excellent water solubility—easily dissolves in water, making it suitable for various formulations.
1.6 Stable—resistant to spontaneous oxidation, discoloration, and decomposition, with excellent stability against light, heat, and pH variations.
CongenPharma produces and supplies dual-patent, high-quality ergothioneine active ingredient.
CongenPharma is a manufacturer of ergothioneine active ingredient and has established a close collaboration with Zhejiang University. We have achieved multiple breakthroughs in ergothioneine synthesis technology, enabling the mass production of high-purity ergothioneine. This innovation helps brand customers reduce costs and improve efficiency, empowering them to stand out in the efficacy-focused skincare market. Compared to commercially available ergothioneine products, Tongjun Pharmaceutical's CG Ergt ergothioneine boasts superior advantages such as ultra-high purity, premium concentration, exceptional efficacy, and eco-friendly, sustainable production—plus, it offers a significant price advantage at the consumer level. Feel free to reach out for inquiries or request samples!
CongenPharma is your trust manuafcturer for Ergothioneine (EGT) with high-quality ergothioneine active ingredient.
