SNAC [N-8-(2-hydroxybenzamide) octanoate sodium]: A premium choice of excipient for semaglutide, how to choose the right SNAC supplier
Publish Time:
2025-09-01
In the field of pharmaceutical excipients, there is a product that has attracted significant attention for its remarkable enhancement of oral drug absorption efficiency — SNAC, chemically known as N-8-(2-hydroxybenzamide) octanoate sodium. As a highly effective intestinal permeation enhancer, SNAC plays a key role in oral peptide drug formulations, especially in the currently popular semaglutide formulations, where it is one of the core excipients, laying an important foundation for the clinical application of oral semaglutide.
From the product's nature, SNAC possesses excellent biocompatibility and stability, making it a "darling" in pharmaceutical research and development. During oral drug delivery, it effectively overcomes the intestinal absorption barrier, promoting the permeation and absorption of drug molecules, solving many issues related to the low oral bioavailability of peptide drugs. Taking semaglutide as an example, an important drug for treating type 2 diabetes and obesity, the development of its oral formulation has always been a focus in the industry. SNAC, as an excipient for semaglutide, significantly enhances the absorption of oral semaglutide through its unique mechanism, allowing patients to avoid injections, greatly improving medication convenience and adherence, and promoting the market adoption of semaglutide formulations.
For pharmaceutical companies, research institutions, and other demand-side entities, after understanding the core value of SNAC (N-8-(2-hydroxybenzamide) octanoate sodium), choosing a reliable SNAC supplier becomes a key step to ensure smooth progress in research and production. So, what dimensions should be considered when selecting a quality SNAC supplier? First, product quality assurance is fundamental. A quality supplier must provide clear product quality test reports to ensure that key indicators such as SNAC purity and solubility meet national pharmaceutical industry standards, thereby avoiding quality risks from the source. Second, product quality stability is crucial. The performance of SNAC must remain consistent across different batches, requiring suppliers to have mature production processes and strict quality control procedures to precisely test and control each batch. Third, supply chain capability cannot be overlooked. Pharmaceutical R&D and production require timely raw material supply; suppliers must have stable production capacity and efficient logistics systems to avoid project delays caused by raw material shortages or late deliveries. Finally, technical service support is also important. Professional SNAC suppliers should provide technical consultation, sample trials, and other services to help customers solve issues related to product storage and application compatibility, achieving long-term win-win cooperation.
Core information of SNAC [N-8-(2-hydroxybenzamide) octanoate sodium] is shown in the table below:
| Item | Details |
| Structural formula |
|
| CAS No. | 203787-91-1 |
| Appearance | White or off-white powder, free of visible impurities |
| Molecular formula | C 15 H 20 NNaO 4 |
| Molecular weight | 301.31
|
Purity |
≥99% |
| Single impurities | ≤0.1% |
| Storage conditions | Room temperature, protected from light, stored in a dry place |
| Manufacturer | Guangzhou Tongjun Pharmaceutical Technology Co., Ltd. |
Today, with the continuous expansion of the oral peptide drug market, the demand for SNAC continues to grow. Whether focusing on excipient development for popular drugs like semaglutide or exploring delivery solutions for other oral drugs, SNAC (N-8-(2-hydroxybenzamide) octanoate sodium) shows broad application prospects. Choosing the right SNAC supplier not only ensures high-quality raw material supply but also adds significant value to the success of pharmaceutical projects. In the future, with ongoing pharmaceutical technological innovations, SNAC's role in pharmaceutical excipients will become even more prominent, contributing more to the development of the oral drug industry.
