Acetyl Dipeptide-1 cetyl ester– A soothing and firming peptide that delivers dual benefits, helping sensitive skin combat aging and skip a decade of detours on the anti-aging journey!
Publish Time:
2025-10-24
Sensitive skin urgently demands anti-aging solutions, as consumers face three major pain points: First, heightened reactivity of nerve endings leads to persistent pain, redness, and itching; second, while seeking effective anti-aging treatments, consumers "dare not use potent ingredients" due to concerns that complex formulations may exacerbate sensitivity; and third, stress intensifies skin sensitivity and triggers "facial breakdown," driving a new demand for emotionally mindful skincare approaches.
CongenPharma CALM’nLIFT ® Acetyl Dipeptide-1 cetyl ester ) as the core, it combines "soothing stress relief" and "firming & lifting" into one, perfectly aligning with the demand for streamlined ingredients and reduced burden. This allows sensitive skin to achieve anti-aging results in a single step, helping you avoid unnecessary detours.
I. Background: Derived from an Endogenous Analgesic Dipeptide
Acetyl Dipeptide-1 Cetyl Ester was developed based on the "Kyoto Peptide" (tyrosine-arginine dipeptide), discovered in 1979 by Kyoto University in Japan. Although this endogenous dipeptide can release endorphins for analgesic effects, it is unable to penetrate the dermal layer. *
After acetylation + cetyl esterification modification, it not only enhances transdermal permeability but also improves stability. It still retains its activity in releasing the "happiness hormone" endorphin, allowing the efficacy to be better realized.
△The Structure of Acetyl Dipeptide-1 Cetyl Ester
II. Dual Benefits: Nerve Relaxation + Firming & Anti-Aging
1. Soothe and Relieve Stress, Calming Sensitive Skin
As a "neurocalming peptide," Acetyl Dipeptide-1 Cetyl Ester provides immediate relief from inflammatory responses such as skin pain, redness, heat, and itching. Its mechanism involves promoting the expression of the pro-opiomelanocortin (POMC) gene to enhance β-endorphin production, while simultaneously reducing the release of pro-inflammatory neuropeptides like Substance P and CGRP. Additionally, it inhibits the activation of the capsaicin receptor TRPV1, thereby decreasing the heightened reactivity of nerve endings and restoring a comfortable state to the skin. *
2. Lifting and Firming: Fighting Against Aging
As a "Lifting and Firming Peptide," it effectively combats sagging and helps define the jawline. Its anti-aging mechanism works by neutralizing oxidative stress and reducing glycation to minimize external damage. Additionally, it inhibits the expression of IL-6 and matrix metalloproteinases (MMPs), thereby preventing collagen degradation while simultaneously promoting elastin and fibrous tissue production, ultimately maintaining skin firmness and youthful vitality. #
III. Efficacy Verification
1. Rapid onset of skin redness and itching
Under P substance stimulation, the number of dilated epidermal blood vessels decreased by 22%, and their area reduced by 36.2%.
In vivo study results also showed that, compared to the placebo, Acetyl Dipeptide-1 Cetearyl Ester significantly reduced reactivity to external stimuli.
△ Left: Sandpaper stimulation; Right: Thermal stimulation
Capsaicin stimulation test: Acetyl Di-Peptide-1 Cetyl Ester takes effect within 1 minute and provides sustained relief from sensitive irritation.
△ Capsaicin Stimulation Test
41 subjects with eyelid eczema applied the product containing this ingredient twice daily, resulting in immediate relief from itching, stinging, and burning sensations. Over 14 and 28 days, symptoms such as scaling, erythema, and swelling continued to improve significantly. ^
2. Define the contours for a sharper jawline
In vitro experiments demonstrated the ability to scavenge free radicals, reduce AGEs formation, inhibit IL-6 and MMPs activity, and enhance the expression of Type I and Type III collagen. #
△Left: Scavenging Free Radicals; Right: Inhibiting AGEs
△Inhibition of IL-6 and MMPs under the photoaging model
Increase the expression of Col1/Col3 collagen synthesis genes
16-week human study: Twice-daily application of the cream containing this ingredient resulted in significant improvements across multiple parameters, including a 9% reduction in jawline laxity, a 10% overall facial lift, and an 11% improvement in the appearance of nasolabial folds, demonstrating clear efficacy advantages that enhance consumer perception. **
IV. Application Scenarios
CALM’nLIFT ® is suitable for a wide range of scenarios, including:
Core scenarios: sensitive skin anti-aging, emotional skincare, instant soothing, and firming & lifting effects.
Precision Care: Gentle Skincare for Delicate Skin Around Eyes and Lips
Special Repair: Pre- and Post-Phototherapy Treatment, Post-Sun Soothing Care
Cross-border Application: Add to hair care products to soothe sensitive scalp conditions.
CongenPharma is your trust partner for cosmetic active ingredients.
For detailed information and sample requests, please contact us whatsapp:+8613380081396 email:shine@congenpharm.com
*Cui Benwen, Lin Mengjun, Wang Huihui, et al. Cosmetic Peptides with Anti-Allergic and Soothing Efficacy[J]. Journal of Daily Chemicals Science, 2023, 46(05): 51-55. DOI: CNKI:SUN:RYHX.0.2023-05-011.*
# Yang Jiali , He Shengsheng, Ke Hui, et al. Skin Anti-Aging Effects and Mechanisms of Acetyl Di-Peptide-1 Ceteryl Ester[J]. Journal of China Pharmaceutical University, 2023, 54(02):188-197. DOI: CNKI:SUN:ZGYD.0.2023-02-007.
^ Tan J, Demessant A, Le Dantec G, Le Floc'h C, Kerob D. Tolerance and Efficacy of a Dermocosmetic Formulation Containing Neurosensine in Subjects with Eyelid Eczema. Clinical, Cosmetic & Investigational Dermatology 2023;16
**18228 A novel acetyl dipeptide exhibits pleiotropic gene expression, optimized bioavailability, and perceived anti-aging benefits; 27886 Optimized delivery of a novel acetyl dipeptide delivers clinically and consumer-perceivable benefits to the anti-aging attributes of the lower face, including firming and enhancement of jawline contour.
