New patent, new ingredient | Congen Crystal High-Gloss Ring Peptide, creating a translucent crystal skin

Publish Time:

2025-07-29


Radiant, hydrated, and crystal-like... these keywords have swept the global beauty market, representing the common pursuit of ideal skin among consumers.

 

Recently, CongenPharma's independently developed Decanoyl cyclotetrapeptide has been granted a Chinese patent , patent number: ZL202510235238.0. This innovative ingredient, hailed as the "crystal highlight cyclopeptide," provides a new scientific solution for creating "luminous crystal skin".

 

Is it the scientific answer to radiant skin?

1. Stable 
→ The cyclic structure resists enzymatic degradation, resulting in longer-lasting activity.

 

2. Mild and effective 
→ The safe concentration is 4 times that of linear peptides, suitable for sensitive skin;

The cyclic structure more easily binds to receptor sites, enabling precise action;

→ Better transdermal penetration, easier absorption by the skin.

 

Triple highlight engine, creating "crystal skin"

→ Even and luminous: Increases α-crystallin, reduces the accumulation of damaged proteins, making skin translucent like crystal;

→ Strengthens the barrier: Promotes the production of filaggrin, resulting in a dense, damage-resistant stratum corneum, presenting healthy beauty;

→ Hydrated and plump: Upregulates hyaluronic acid, providing excellent water retention, making skin soft and radiant.

 

Comparative experiment: Cyclotetrapeptide outperforms linear peptide

 

Reduced cytotoxicity, safe concentration is 4 times that of linear peptide

Linear tetrapeptides show significant cytotoxicity at 80μM, with relative cell activity dropping to approximately 55%. The cyclized tetrapeptide shows significantly reduced cytotoxicity, with no significant cytotoxicity at 80μM, demonstrating good biosafety.

 


α-Crystallin increased by 2.06 times

Using hydrogen peroxide to stimulate human epidermal cells (HaCaT) to create a model, the experiment shows that Decanoyl cyclotetrapeptide enhances α-crystallin expression 2.06 times more effectively than Palmitoyl tetrapeptide-10.

 

 

Filaggrin increased by 2.53 times, hyaluronic acid increased by 4.22 times

 

5 scenarios, unlock "crystal skin" with one click 
 

Daily skincare: "Apply-on hydro-boosting serum", radiant glow

Emergency rescue for fatigue: Rescues dullness caused by staying up late, overtime, and fatigue

Brightening for sensitive skin: Mild and effective, precisely targets inflammation and pigmentation

Post-sun care: Counteracts the accumulation of damaged proteins, strengthens the barrier

Synergistic youthfulness: Hydrated and plump, fine lines are invisible

 

Innovative raw materials, collaborative application

Contact us to obtain detailed product information:marketing@congenpharm.com