Your Trust Supplier | CG AKE® – A Cosmetic Peptide for Expression Lines & Skin Smoothing
Publish Time:
2026-09-29
CG AKE® – A Cosmetic Peptide for Expression Lines & Skin Smoothing
INCI Name: Dipeptide Diaminobutyroyl Benzylamide Diacetate
CAS No.: 823202-99-9
Synonym: SYN-AKE
Purity: ≥95.0%
Solubility: Water soluble
CG AKE® is a functional cosmetic peptide developed for expression line care, wrinkle reduction and skin smoothing. Its performance has been evaluated through both in vitro muscle contraction testing and human volunteer studies.
1. In Vitro Muscle Contraction Test
The cosmetic efficacy of CG AKE® was evaluated using an in vitro model of innervated muscle cells.
At a concentration of 0.5 mM, CG AKE® was evaluated by measuring muscle contraction frequency over the culture period.
Test Results
Compared with the control group, CG AKE® demonstrated a significant reduction in muscle contraction activity.
The observed characteristics of the effect were:
Fast-acting · Long-lasting · Reversible
These findings support the application of CG AKE® in cosmetic formulations designed to improve the appearance of expression lines and fine lines.
2. In Vivo / Human Volunteer Study – Wrinkle Reduction & Skin Smoothing
A 28-day human volunteer study was conducted to evaluate the wrinkle-reducing and skin-smoothing effects of CG AKE3000.
Study Design
- Number of volunteers: 45
- Test period: 28 consecutive days
- Application frequency: Twice daily
- Test product: CG AKE3000
- CG AKE3000 concentration: 4% in the tested formulation
- Reference group: Formulation containing 10% Acetyl Hexapeptide-8 (100 ppm)
- Control group: Blank formulation
Participants applied each product according to the recommended application procedure.
Instrumental Evaluation
Skin surface topography was evaluated using several parameters, including:
- Ra – Average Roughness: The average surface roughness value of the measured skin area.
- Rt – Total Roughness: The vertical distance between the highest peak and lowest valley of the measured profile.
- Rz – Mean Roughness Depth: The average value derived from the maximum peak-to-valley measurements.
28-Day Results
After 28 days of continuous use, the CG AKE3000 group demonstrated:
- A significant reduction in the appearance of forehead expression lines
- Improved skin surface smoothness
- Reduced skin roughness parameters
- Improved overall wrinkle appearance
For the evaluated parameters, the CG AKE3000 formulation demonstrated stronger measured efficacy than the reference formulation under the conditions of this study.
3. Crow's Feet / Eye-Area Wrinkle Study
The smoothing and anti-wrinkle effects of CG AKE3000 were also evaluated on the crow's feet area around the eyes.
A lotion containing 4% CG AKE3000 was applied to the eye-corner area continuously for 28 days.
Observed Results
After 28 days:
- Wrinkle depth was visibly reduced
- The overall appearance of wrinkles was improved
- The skin around the eye area appeared smoother
These findings indicate that CG AKE3000 has potential for use in eye-care and anti-aging skincare formulations targeting expression lines and visible wrinkles.
4. Key Cosmetic Benefits of CG AKE3000
Based on the available testing data, CG AKE3000 can be positioned as a cosmetic peptide for:
Expression Line Care
Helps improve the visible appearance of expression-related lines.
Wrinkle Care
Supports the reduction of visible forehead and eye-area wrinkles.
Skin Smoothing
Helps improve measurable skin surface roughness and the appearance of skin texture.
Eye Contour Care
Suitable for formulations targeting crow's feet and visible eye-area wrinkles.
A Multi-Level Approach to Expression Line Care
CG AKE® combines in vitro mechanism-related testing with human volunteer efficacy evaluation, providing a broader evidence base for cosmetic anti-aging applications.
From muscle contraction testing to visible wrinkle improvement — CG AKE® is designed for modern peptide-based anti-aging skincare.
The efficacy statements above are based on the specified test conditions and formulations. Results may vary depending on formulation, concentration, application method and individual skin conditions.
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