Cosmetic Active Ingredient Manufacturer – Ingredient Literacy: Acetyl Tetrapeptide-5, for Eye Bags/Dark Circles/Droopy Eyes *Please lock this up!
Publish Time:
2026-01-16
Core positioning: A tetrapeptide that has been empirically proven to improve under-eye bags and dark circles.
Application scenarios: Eye creams, eye masks, and eye serums designed for night owls, early-morning commuters, and those experiencing aging and sagging around the eyes.
Well-known brands used: La Prairie, Chanel, Hanse etc.
I. Basic Information
INCI Name: Acetyl Tetrapeptide-5
Also known as: Eye-Lite Peptide, Eye-Serine Peptide
CAS Number: 820959-17-9
Structural properties: synthetically produced tetrapeptide, molecular weight 492.5 g/mol
Physicochemical properties: Water-soluble, highly compatible with formulations, and suitable for a wide pH range.
Effective concentration: 0.001%–3%; a concentration of 0.1% already shows significant efficacy.
II. Core Efficacy and Mechanism of Action
01 Promotes circulation and alleviates puffy under-eye bags + vascular dark circles
Edematous under-eye bags are often caused by poor blood circulation around the eyes and accumulation of interstitial fluid that leaks out. Vascular dark circles, on the other hand, are associated with venous stasis around the eyes and a decrease in blood oxygen saturation.
As an ACE inhibitor, it blocks the catalytic activity of angiotensin-converting enzyme, inhibiting the production of angiotensin II. This helps relieve ocular pressure, promote blood circulation around the eyes, reduce leakage of interstitial fluid, and alleviate edematous under-eye bags and vascular dark circles.
02 Anti-glycation, improves aging-related under-eye bags + loose, dull skin around the eyes.
Skin glycation leads to cross-linking of collagen fibers, resulting in dull, yellowish skin, loose and sagging skin, wrinkles, and lax-type under-eye bags.
Acetyl Tetrapeptide-5 can enhance the activity of SOD, reduce the formation of advanced glycation end products (AGEs), block the binding of AGEs to collagen and elastin, prevent cross-linking and degeneration of collagen fibers, and improve the elasticity of the dermal layer, thereby alleviating age-related eye bags, periorbital laxity, and dullness.
III. Comparative Analysis of Ingredient Advantages
01 Longer-lasting than caffeine
Caffeine provides only an immediate anti-swelling effect, while Acetyl Tetrapeptide-5 offers long-lasting reduction in the volume of under-eye bags and helps improve dark circles!
02 More precise than Bi Zhi Ti
Most plant extracts improve the eye area through “blurred conditioning”—a mechanism that involves well-defined active peptides. Clinical evidence shows these peptides effectively reduce puffiness under the eyes in just 14 days and lighten dark circles in 28 days. The results are visible and backed by solid scientific evidence; this is not pseudoscience.
03 Even sensitive skin can handle it.
Extremely low irritation—no need to build up tolerance. Safe for use around the delicate eye area and on sensitive skin; it won’t leave your skin drier the more you use it!
IV. Formulation Blending Approach
Synergistic combination:
Instant + Long-lasting: Acetyl Tetrapeptide-5 + Caffeine
Reduces swelling + anti-wrinkle: Acetyl Tetrapeptide-5 + Acetyl Hexapeptide-8
Light Dark + Brightening: Acetyl Tetrapeptide-5 + VC
Sensitive skin compatibility: Acetyl Tetrapeptide-5 + Ceramide + Hyaluronic Acid
CongenPharma is your trust Acetyl Tetrapeptide-5 manufacturer , welcome to reach us.
Relevant Information
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