Supplier Data: How effective is Hexapeptide-2 in terms of whitening?
Publish Time:
2025-11-26
Whitide® II Hexapeptide-2, known in INCI as HEXAPEPTIDE-2, is a biomimetic whitening peptide antagonist of α-MSH. Its chemical structure exhibits excellent affinity for MC1-R. It can competitively bind to MC1-R on melanocytes, blocking the signaling pathway of α-MSH and thereby inhibiting melanin production. It is widely used in cosmetics, including brightening serums, whitening face creams, concealing creams, foundations, hand creams, and more.
Schematic diagram of the whitening mechanism of Hexapeptide-2
The melanin synthesis assay using B16F10 cells showed that, compared to the model group, the melanin synthesis inhibition rates induced by 1%, 0.1%, and 0.01% of Whitide® II hexapeptide-2 were 69.38%, 46.31%, and 11.59%, respectively, demonstrating statistically significant differences.
The chemical structure of Hexapeptide-2 exhibits excellent affinity for MC1-R as well. It can bind to MC1-R on melanocytes ahead of time, blocking the signaling pathway of α-MSH and thereby inhibiting melanin production. Furthermore, based on epigenetic studies, Hexapeptide-2 suppresses melanin synthesis at the genetic level by regulating the expression of two miRNAs—miR-29 and miR-218—while simultaneously promoting collagen synthesis, thus achieving a multi-faceted whitening effect.*
Results from semi-face human testing on 35 Asian subjects (whitening test cycle: 56 days; anti-wrinkle test cycle: 42 days) show that 1% hexapeptide-2 exhibits effects such as skin brightening, reduction of pigmentation spots, alleviation of erythema, and improvement of dullness. Additionally, it can reduce the number, area, depth, and length of wrinkles.
Hexapeptide-2 exhibits remarkable whitening effects. For detailed information, please contact your trust parnter : Guangzhou Congen Pharmatec Co.,Ltd.
