High purity 99% Fmoc-AEEA-OH (CAS:166108-71-0): Core intermediate of Semaglutide and Tirzepatide
Publish Time:
2025-09-05
In the global field of glucose-lowering and weight-loss drugs, the efficient synthesis of semaglutide and tirzepatide relies on high-quality intermediates. Purity 99% Fmoc-AEEA-OH (CAS No.:166108-71-0), as a high-performance intermediate for semaglutide and tirzepatide, has become a core raw material for biopharmaceutical companies, directly determining the purity, safety, and efficacy of downstream drugs.
1. Core Advantage: Why Choose T Tongjun Pharmaceutical Purity 99% Fmoc-AEEA-OH (CAS No.:166108-71-0)
Fmoc-AEEA-OH (CAS No.:166108-71-0, chemical name [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid), with 99% purity, has significant advantages in intermediate applications: low-purity products contain Fmoc deprotection impurities and amino oxidation by-products, which easily cause peptide chain mismatches and increase purification costs; 99% purity can control impurities below 1%, ensuring continuous and accurate peptide chain extension, improving the finished drug purity to over 99.5%, and reducing safety risks.
2. Semaglutide Synthesis: A Key Bridging Role
Semaglutide requires PEGylation modification through a spacer arm to extend its half-life. Purity 99% Fmoc-AEEA-OH (CAS No.:166108-71-0), as a core semaglutide intermediate, its carboxyl group can precisely form an amide bond with the drug precursor amino group, introducing a flexible chain; high purity also avoids impurity interference at the modification site, effectively enhancing the drug's in vivo stability (half-life up to 7 days) and bioavailability. In practical applications, it can increase semaglutide synthesis yield by 15%-20% and shorten purification cycles by 25%.
3. Tirzepatide Synthesis: Irreplaceable Value
Tirzepatide has a complex molecular structure and requires high selectivity for intermediates. Purity 99% Fmoc-AEEA-OH (CAS No.:166108-71-0), as a tirzepatide intermediate, the ether oxygen bond can reduce steric hindrance in multi-chain connections, ensuring peptide bond connection efficiency; 99% purity can prevent inter-chain mislinking, ensuring molecular structural integrity. At the same time, it can improve drug water solubility, reduce storage aggregation, and extend shelf life, making it the preferred choice for mainstream domestic pharmaceutical companies producing tirzepatide.
4. Quality Assurance and Application Advantages
Manufacturer: Guangzhou Tongjun Pharmaceutical Technology Co., Ltd. states: Purity 99% Fmoc-AEEA-OH (CAS No.:166108-71-0) must undergo strict quality control: HPLC tests purity stable at 99.0%-99.5%, moisture content ≤1%, fully meeting the production requirements of both drugs; each batch provides a COA to ensure traceability compliance. Compared to ordinary purity products, it can improve synthesis efficiency and finished product purity, reduce optimization costs, and will continue to support peptide drug production in the future.
